Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs

Fernando Cánovas; David Planes-Muñoz; Miren Jaione Zurbano; Pablo Messia; María Isabel Vasallo

doi:doi:10.11648/j.wjfst.20230703.11

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Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs

Fernando Cánovas, David Planes-Muñoz, Miren Jaione Zurbano, Pablo Messia, María Isabel Vasallo

Published in World Journal of Food Science and Technology (Volume 7, Issue 3)

Received: 31 May 2023 Accepted: 19 June 2023 Published: 6 July 2023

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Abstract

Osteoarthritis has become one of the most prevalent conditions that affect joints in dogs. Cartilage degradation and subsequent chronic inflammatory process affect synovial membranes, induce pain and decrease joint functionality. The aim of this research is to study the effects of supplementation with a nutraceutical based on internal egg shell membrane in dogs diagnosed with osteoarthritis in knee or hip joints. During a consumption period of 10 weeks, efficacy was evaluated in a placebo controlled clinical trial. Bioarth functional scale (BAS) was used to estimate joint functionality. Serum levels of C-telopeptides of type II collagen (CTx-II) were also collected as a biomarker of osteoarthritis. Functional limitation and joint mobility parameters showed an improvement by a decrease of BAS scores, although muscle atrophy showed no differences between any of the groups or periods considered in this study. Sterilization seems to have a higher influence in that parameter, indicating sex and condition as confounding variables. Antalgic postures significantly decreased in treatment group therefore indicating an improvement in the quality of life of subjects. Despite the fact that biomarker CTx-II has been used frequently in evaluation of cartilage degradation, no significant differences were observed in this study, although individual analysis revealed a greater reduction in a higher percentage of dogs from the treatment group. Osteoarthritis is a long-term disease, often frustrating for both veterinaries and owners. ESM could become a safe, effective alternative for chronic, long-term management of osteoarthritis in dogs.

Published in	World Journal of Food Science and Technology (Volume 7, Issue 3)
DOI	10.11648/j.wjfst.20230703.11
Page(s)	41-47
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Knee Pain, Hip Pain, Nutraceutical, Joint Functionality, Bioarth Assessment Scale

References

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APA Style

Fernando Cánovas, David Planes-Muñoz, Miren Jaione Zurbano, Pablo Messia, María Isabel Vasallo. (2023). Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World Journal of Food Science and Technology, 7(3), 41-47. https://doi.org/10.11648/j.wjfst.20230703.11

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ACS Style

Fernando Cánovas; David Planes-Muñoz; Miren Jaione Zurbano; Pablo Messia; María Isabel Vasallo. Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World J. Food Sci. Technol. 2023, 7(3), 41-47. doi: 10.11648/j.wjfst.20230703.11

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AMA Style

Fernando Cánovas, David Planes-Muñoz, Miren Jaione Zurbano, Pablo Messia, María Isabel Vasallo. Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World J Food Sci Technol. 2023;7(3):41-47. doi: 10.11648/j.wjfst.20230703.11

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@article{10.11648/j.wjfst.20230703.11,
  author = {Fernando Cánovas and David Planes-Muñoz and Miren Jaione Zurbano and Pablo Messia and María Isabel Vasallo},
  title = {Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs},
  journal = {World Journal of Food Science and Technology},
  volume = {7},
  number = {3},
  pages = {41-47},
  doi = {10.11648/j.wjfst.20230703.11},
  url = {https://doi.org/10.11648/j.wjfst.20230703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjfst.20230703.11},
  abstract = {Osteoarthritis has become one of the most prevalent conditions that affect joints in dogs. Cartilage degradation and subsequent chronic inflammatory process affect synovial membranes, induce pain and decrease joint functionality. The aim of this research is to study the effects of supplementation with a nutraceutical based on internal egg shell membrane in dogs diagnosed with osteoarthritis in knee or hip joints. During a consumption period of 10 weeks, efficacy was evaluated in a placebo controlled clinical trial. Bioarth functional scale (BAS) was used to estimate joint functionality. Serum levels of C-telopeptides of type II collagen (CTx-II) were also collected as a biomarker of osteoarthritis. Functional limitation and joint mobility parameters showed an improvement by a decrease of BAS scores, although muscle atrophy showed no differences between any of the groups or periods considered in this study. Sterilization seems to have a higher influence in that parameter, indicating sex and condition as confounding variables. Antalgic postures significantly decreased in treatment group therefore indicating an improvement in the quality of life of subjects. Despite the fact that biomarker CTx-II has been used frequently in evaluation of cartilage degradation, no significant differences were observed in this study, although individual analysis revealed a greater reduction in a higher percentage of dogs from the treatment group. Osteoarthritis is a long-term disease, often frustrating for both veterinaries and owners. ESM could become a safe, effective alternative for chronic, long-term management of osteoarthritis in dogs.},
 year = {2023}
}

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TY - JOUR
T1 - Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs
AU - Fernando Cánovas
AU - David Planes-Muñoz
AU - Miren Jaione Zurbano
AU - Pablo Messia
AU - María Isabel Vasallo
Y1 - 2023/07/06
PY - 2023
N1 - https://doi.org/10.11648/j.wjfst.20230703.11
DO - 10.11648/j.wjfst.20230703.11
T2 - World Journal of Food Science and Technology
JF - World Journal of Food Science and Technology
JO - World Journal of Food Science and Technology
SP - 41
EP - 47
PB - Science Publishing Group
SN - 2637-6024
UR - https://doi.org/10.11648/j.wjfst.20230703.11
AB - Osteoarthritis has become one of the most prevalent conditions that affect joints in dogs. Cartilage degradation and subsequent chronic inflammatory process affect synovial membranes, induce pain and decrease joint functionality. The aim of this research is to study the effects of supplementation with a nutraceutical based on internal egg shell membrane in dogs diagnosed with osteoarthritis in knee or hip joints. During a consumption period of 10 weeks, efficacy was evaluated in a placebo controlled clinical trial. Bioarth functional scale (BAS) was used to estimate joint functionality. Serum levels of C-telopeptides of type II collagen (CTx-II) were also collected as a biomarker of osteoarthritis. Functional limitation and joint mobility parameters showed an improvement by a decrease of BAS scores, although muscle atrophy showed no differences between any of the groups or periods considered in this study. Sterilization seems to have a higher influence in that parameter, indicating sex and condition as confounding variables. Antalgic postures significantly decreased in treatment group therefore indicating an improvement in the quality of life of subjects. Despite the fact that biomarker CTx-II has been used frequently in evaluation of cartilage degradation, no significant differences were observed in this study, although individual analysis revealed a greater reduction in a higher percentage of dogs from the treatment group. Osteoarthritis is a long-term disease, often frustrating for both veterinaries and owners. ESM could become a safe, effective alternative for chronic, long-term management of osteoarthritis in dogs.
VL - 7
IS - 3
ER -

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Author Information

Fernando Cánovas

Faculty of Veterinary, Universidad Católica de Murcia, Murcia, Spain
David Planes-Muñoz
Miren Jaione Zurbano

Veterinary Center Lur Gorri-Bara?áin, Plaza Lur Gorri, Bara?ain, Navarra, Spain
Pablo Messia

Veterinary Center Lur Gorri-Orkoien, Plaza Mendikur, Orcoyen, Navarra, Spain
María Isabel Vasallo

San Antonio Technologies-Universidad Católica San Antonio de Murcia, Murcia, Spain

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Fernando Cánovas, David Planes-Muñoz, Miren Jaione Zurbano, Pablo Messia, María Isabel Vasallo. (2023). Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World Journal of Food Science and Technology, 7(3), 41-47. https://doi.org/10.11648/j.wjfst.20230703.11

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ACS Style

Fernando Cánovas; David Planes-Muñoz; Miren Jaione Zurbano; Pablo Messia; María Isabel Vasallo. Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World J. Food Sci. Technol. 2023, 7(3), 41-47. doi: 10.11648/j.wjfst.20230703.11

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AMA Style

Fernando Cánovas, David Planes-Muñoz, Miren Jaione Zurbano, Pablo Messia, María Isabel Vasallo. Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs. World J Food Sci Technol. 2023;7(3):41-47. doi: 10.11648/j.wjfst.20230703.11

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@article{10.11648/j.wjfst.20230703.11,
  author = {Fernando Cánovas and David Planes-Muñoz and Miren Jaione Zurbano and Pablo Messia and María Isabel Vasallo},
  title = {Randomized Clinical Trial to Analyze the Efficacy of an Eggshell Membrane Dietary Supplementation in the Concomitant Treatment of Osteoarthritis in Dogs},
  journal = {World Journal of Food Science and Technology},
  volume = {7},
  number = {3},
  pages = {41-47},
  doi = {10.11648/j.wjfst.20230703.11},
  url = {https://doi.org/10.11648/j.wjfst.20230703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjfst.20230703.11},
  abstract = {Osteoarthritis has become one of the most prevalent conditions that affect joints in dogs. Cartilage degradation and subsequent chronic inflammatory process affect synovial membranes, induce pain and decrease joint functionality. The aim of this research is to study the effects of supplementation with a nutraceutical based on internal egg shell membrane in dogs diagnosed with osteoarthritis in knee or hip joints. During a consumption period of 10 weeks, efficacy was evaluated in a placebo controlled clinical trial. Bioarth functional scale (BAS) was used to estimate joint functionality. Serum levels of C-telopeptides of type II collagen (CTx-II) were also collected as a biomarker of osteoarthritis. Functional limitation and joint mobility parameters showed an improvement by a decrease of BAS scores, although muscle atrophy showed no differences between any of the groups or periods considered in this study. Sterilization seems to have a higher influence in that parameter, indicating sex and condition as confounding variables. Antalgic postures significantly decreased in treatment group therefore indicating an improvement in the quality of life of subjects. Despite the fact that biomarker CTx-II has been used frequently in evaluation of cartilage degradation, no significant differences were observed in this study, although individual analysis revealed a greater reduction in a higher percentage of dogs from the treatment group. Osteoarthritis is a long-term disease, often frustrating for both veterinaries and owners. ESM could become a safe, effective alternative for chronic, long-term management of osteoarthritis in dogs.},
 year = {2023}
}

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