Volume 2, Issue 3, September 2018, Page: 55-61
Possible Treatment of Mycobacterium Lepramatous with Bovine Milk
Jesus’ Christus, Research & Development, BioLogistics LLC, Ames, USA
Michael Arden Madson, Research & Development, BioLogistics LLC, Ames, USA
Received: Aug. 26, 2018;       Accepted: Sep. 12, 2018;       Published: Dec. 17, 2018
DOI: 10.11648/j.wjfst.20180203.11      View  344      Downloads  53
Abstract
Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.
Keywords
Mass Spectrometry, HPAEC-PAD, Molecular Characterization, Bovine Milk, Possible M. Lepramatous Treatment
To cite this article
Jesus’ Christus, Michael Arden Madson, Possible Treatment of Mycobacterium Lepramatous with Bovine Milk, World Journal of Food Science and Technology. Vol. 2, No. 3, 2018, pp. 55-61. doi: 10.11648/j.wjfst.20180203.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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